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at the Georgia Institute of Technology

Micro & Nano-Enabled Electronics Systems

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Micro-Physiological Systems Series: Bioengineered Human iPSC Tissue Model for Gaining Mechanistic and Therapeutic Insights into CPVT

Speaker: Sung Jin Park, Ph.D. - Assistant Professor, Coulter Department of Biomedical Engineering; Georgia Institute of Technology & Emory University School of Medicine
Wednesday November 20, 2019 | 1:00 pm - 2:00 pm | Whitaker 1103 | 313 Ferst Drive, Atlanta, GA 30332

Abstract: The cellular phenotypes caused by inherited arrhythmia mutations have been studied using human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs). However, arrhythmias are the emergent properties of cells assembled into tissues, and the impact of these mutations on tissue-level properties of human myocardium has not been reported. In this talk, I will present an in vitro hiPSC-CM-based platform to study the tissue-level properties of engineered human myocardium. I will illustrate how this hiPSCCM- based platform can be used to investigate pathogenic mechanisms in the deadly, exercise-triggered inherited arrhythmia catecholaminergic polymorphic ventricular tachycardia (CPVT). In addition, I will show how we combined this novel platform with genome editing and identified new therapeutic target for CPVT.

Lunch Provided at 1pm

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Upcoming Events

IEN is home to one of the sixteen sites of the National Nanotechnology Coordinated Infrastructure (NNCI). The NNCI was initiated by the National Science Foundation (NSF) in 2015 to provide researchers from academia, industry, and government access to university user facilities with leading-edge fabrication and characterization tools, instrumentation, and expertise within all disciplines of nanoscale science, engineering and technology.

IEN, in partnership with the Joint School of Nanoscience and Nanoengineering (JSNN) in Greensboro, NC, created the Southeastern Nanotechnology Infrastructure Corridor (SENIC)providing research and educational resources to students, researchers, and educators in the southeast US and beyond. In addition, IEN serves as the Coordinating Office for the NNCI network.


Strategic Contacts

Senior Leadership
Dr. Oliver Brand; Executive Director [oliver.brand@ece.gatech.edu]
Dr. Eric M. Vogel; Deputy Director [eric.vogel@mse.gatech.edu]

Research Areas
Micro & Nano Enabled Electronic Systems
Dr. Eric M. Vogel  [eric.vogel@mse.gatech.edu]

Nanotechnology at Georgia Tech
Dr. Oliver Brand [oliver.brand@ece.gatech.edu]
Dr. David Gottfried [david.gottfried@ien.gatech.edu]

Core Facilities
Fabrication Laboratories
Mr. Gary Spinner [gary.spinner@ien.gatech.edu]

Materials Characterization
Mr. Walter Henderson [walter.henderson@ien.gatech.edu]

Shared User Access
Dr. Paul Joseph [paul.joseph@ien.gatech.edu]

Dr. David Gottfried [david.gottfried@ien.gatech.edu]

Education Programs
Dr. Quinn Spadola [quinn.spadola@ien.gatech.edu]

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